Since that time, a list of banned substances has been constantly updated by the International Olympic Committee (IOC) and the World Anti-doping Agency (WADA). Despite centuries of reports of using substances to enhance athletic performance, testing athletes for the use of performance-enhancing drugs began only in 1968 ( Barroso et al., 2008 Botrè, 2008). ![]() With the huge financial incentives and the subsequent pressures to excel associated with the international sporting industry, attempts to achieve a competitive edge especially with the use of performance-enhancing drugs have only been increasing ( Barroso et al., 2008). The most common analytical strategies currently followed by the anti-doping laboratories accredited by the WADA are discussed along with the challenges laboratories face for the analysis of this diverse class of drugs.įor as long as sporting events have existed, the desire to gain a competitive edge has been present as well. This review provides an overview of the pharmacology and toxicology of diuretics and discusses their application in sports. Because of their abuse by athletes, diuretics have been included on The World Anti-Doping Agency's (WADA) list of prohibited substances the use of diuretics is banned both in competition and out of competition and diuretics are routinely screened for by anti-doping laboratories. ![]() Diuretics are often abused by athletes to excrete water for rapid weight loss and to mask the presence of other banned substances. There are several major categories of this drug class and the compounds vary greatly in structure, physicochemical properties, effects on urinary composition and renal haemodynamics, and site and mechanism of action. Diuretics are drugs that increase the rate of urine flow and sodium excretion to adjust the volume and composition of body fluids.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |